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Posted by john on August 26th, 2007 — in Fioricet News
MUMBAI, Aug. 20, 2007 (Thomson Financial delivered by Newstex) — Indian pharma company Ranbaxy Laboratories Ltd said it secured Food and Drug Administration approval to manufacture and sell pain relief drugs Hydrocodone Bitartrate and Acetaminophen tablets US Pharmacopeia (NASDAQ:PCOP) in the US.
Jim Meehan, vice president of sales and marketing, Ranbaxy Pharmaceuticals Inc said the new drugs — to be launched in November — will further expand the company’s portfolio.
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Annual sales for Hydrocodone Bitartrate and Acetaminophen tablets in 2006 was 390.6 mln usd, Ranbaxy said in a statement to the Bombay (OTCBB:BBAO) Stock Exchange.
Copyright AFX News Limited 2007. All rights reserved.
The copying, republication or redistribution of AFX News Content, including by framing or similar means, is expressly prohibited without the prior written consent of AFX News.
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Posted by john on August 19th, 2007 — in Fioricet News
Lazaro Puerto, 45, of Kendale Lakes, Fla., is a tough guy. He spent 13 years driving a concrete truck, wheeling it into position, climbing up the ladder in back, slinging the chute back and forth to distribute the wet concrete, 22 tons to a load.
All that hard work contributed to a herniated disc in his neck, a debilitating condition that resulted in crippling pain.
On Aug. 2, Puerto became one of the first dozen patients in the country to receive a stainless steel replacement disc that could offer hope to hundreds of thousands of people nationwide who suffer from neck pain.
Puerto realized he had a herniated disc three months ago, when the pain in his neck got so bad he could no longer drive or even play in the yard with his daughter, Lexa Victoria, 10, and his dogs Princess and Titan.
“And I don’t take pain relievers for it, because I don’t want to damage my liver,” he said.
In a two-hour operation at Miami’s Baptist Hospital, he received the replacement disc, which is designed to ease pain and, unlike old procedures, restore a greater range of motion in his neck.
The FDA approved the Prestige Cervical Disc, by Medtronic Sofamor Danek of Memphis, on July 17. It became available August 1, and South Florida doctors got right to work with it.
The implant could replace many of the 200,000 traditional cervical operations performed each year in the United States in which a damaged disc is removed and the vertebrae above and below it are fused with bone grafts, the company said.
In the new procedure, an apparatus screwed into the vertebrae above and below the removed disc rotates on a “ball-and-trough” system to restore motion.
“It’s very slick,” said neurosurgeon Sergio Gonzalez-Arias, medical director of Baptist Hospital’s Neuroscience Center, who led Puerto’s surgery. “It makes a real difference that instead of creating fusion, we’re preserving motion.”
In the neck, the spinal cord and nerves are surrounded by bony vertebrae, which are separated from each other by discs that allow the neck to rotate and bend.
A disc is like a jelly doughnut, made of tough cartilage on the outside and softer material inside, Gonzalez-Arias said. If the disc is damaged, degraded or herniated by disease or injury, some of the “stuffing” comes out, and the disc no longer properly cushions the vertebrae. It leads to intense pain and loss of motion.
Until now, the “gold standard” operation has been to remove the damaged disc and fuse the two vertebrae together with bone grafts and titanium plates. It could stop the pain, but with loss of motion.
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With the new procedure, the disc is replaced by the Prestige Cervical Disc. Attached to the vertebrae with six surgical screws, it restores the neck’s motion in all directions.
“You can bend, rotate, flex, whatever you need to do,” Gonzalez-Arias said.
The new disc is not for every patient, neurosurgeons and Medtronic officials said. It should not be used for:
* Smokers and people with diabetes, who can have problems healing.
* Patients not yet 18, whose bone structure has not fully matured, and elderly patients with fragile bones. No specific ages are precluded, said Medtronic spokesman Bert Kelly, but prospective patients should consult their doctors about bone strength.
* Patients who lack mobility because of arthritis or other reasons.
* Patients whose injuries involve several cervical discs, since the artificial disc must be attached to intact vertebrae.
The FDA, in approving the disc, classifies it as a “high-risk” operation, since it involves surgery so close to the spinal cord, Kelly said. The procedure costs $32,000 to $34,000, about the same as traditional spinal fusion, and some insurance companies are paying for it, he said.
In the two-year clinical trial at 37 hospitals and medical centers that lead to FDA approval, Medtronic inserted the artificial disc in 276 patients selected randomly and performed traditional bone fusion in 265 others. It said the patients who got the artificial disc experienced less neck and arm pain, saw range of motion restored faster and were able to return to work and other activities sooner.
The FDA will require Medtronic to do a seven-year follow-up, reporting yearly.
Neurosurgeons at hospitals not involved in developing the disc expressed general approval of it.
“This is a good procedure, a moderate step forward in treating diseases of the cervical spine,” said Dr. Eric Nottmeier, neurosurgeon and assistant professor of neurosurgery at the Mayo Clinic in Jacksonville, Fla.
Mayo is training its doctors now to use the procedure, Nottmeier said. He estimated the artificial disc could be used in 30 percent to 40 percent of cases previously dealt with by disc fusion.
Medtronic spokesman Kelly said patients in the company’s clinical trials typically got back the range of motion they had before the surgery — not the greater motion of their youth. Most were able to return to old levels of activity — even downhill skiing or truck driving.
Puerto, on the eve of the operation, said he hopes to take advantage of that — up to a point. He has given up the concrete truck. He now hauls groceries for Wal-Mart.
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Posted by john on August 15th, 2007 — in Fioricet News
Selbyville resident Debbie Caldwell suffered a back injury when she was in an auto accident more than four years ago and walking became a chore that she accomplished with the help of a cane.
Running out of options, Caldwell turned to area chiropractors to help her recover.
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“I saw a chiropractor in Fenwick Island and she did very well for me,” Caldwell said.
After a year, she hit a plateau in her recovery and moved onto a different chiropractor who was able to adjust her spine so she no longer needed the cane to walk.
“I totally believe in chiropractors — I had wonderful results,” she said. “I still go for ‘tune-ups.’”
Chiropractic is a health care profession that focuses on disorders of the musculoskeletal system and the nervous system, and the effects of these disorders on general health, according to the American Chiropractic Association.
Patients come seeking relief from back, neck and/or joint pains, but chiropractors can also help patients with headaches, jaw pain and more.
Chiropractor Dr. Michael D. Schierl, of Apple Chiropractics in the Trading Post Plaza in Oak Orchard, said his first encounter with chiropractics was through a friend who was in the profession. When Schierl saw how happy she was with her work and how her patients were responding to the treatments, he decided it was the right field for him.
“I knew I wanted to help people in the same way,” he said.
And that’s just what he did.
Schierl became a chiropractor after graduating from Sherman College of Chiropractic in South Carolina more than 14 years ago.
“When a person comes to me with discomfort, it is usually because a spinal bone has been locked out of its normal position,” Schierl said. “The joint is locked, so there is a loss of range of motion.”
The muscles then have to work harder to compensate for the loss and they begin to ache.
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Through manipulation or alignment, patients find relief, he said.
“The brain communicates with the body through the nerves. The spinal cord runs from the brain through the spine. The spine nerves branch off of the spinal cord and exit the spine through holes that the spinal bones create as they are stacked on top of each other,” he said. “These nerves now go to every muscle, gland and organ.”
When the spinal bones shift out of place, pressure is placed on the nerves causing pain, numbness and discomfort, Schierl said.
“Using a series of gentle maneuvers, the chiropractor unlocks the spinal bones, restoring range of motion, allowing muscles to relax, taking pressure off of the spinal nerves and restoring communication across the nerves,” he said.
Schierl said herniated or bulging disk sufferers can benefit from chiropractic care. He said the spine is aligned taking pressure off the disk allowing it to heal properly.
Chiropractors are trained similar to medical doctors with some exceptions. Schierl said his training allows him to evaluate a patient and recommend a course of action — a treatment regiment with him or a recommendation to see a neurologist, orthopedist or physician.
Debbie Caldwell said she combined chiropractics with massage therapy and found they “work hand in hand.”
Schierl has found the same results. He offers massage therapy to his patients at his new Oak Orchard practice.
In fact, he even had his office designed by Bryant Hastie of Bryant Hastie Designs to ensure a relaxed and tranquil atmosphere. But patients or acquaintances, as Schierl refers to those he treats, are not left waiting long to enjoy their surroundings.
“I hate waiting in doctors’ offices,” Schierl said. “So I try not to keep anyone waiting in mine.”
His patients, ages 10 weeks old to 95 years old, are not kept waiting. They also know when they leave, Schierl will call them that evening to make sure they are doing their “homework.”
“I give them homework every time they leave here,” he said. “Then I call them in the evening to make sure they are following my directions.”
He said there are a few things people need to do after leaving the chiropractor and he stresses with a follow-up call.
“I have really good results,” Schierl said.
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Posted by john on August 10th, 2007 — in Fioricet News
AN alarming number of Australians treating migraines with over-the-counter and prescription pain relievers are at risk of inducing ‘rebound headaches’ caused by medication overuse, experts said.
Research published today by the Medical Journal of Australia (MJA) also found therapy that could prevent migraines was significantly under-utilised, especially in patients with frequent migraines.
The author of the study, Associate Professor Richard Stark, said many Australian migraine sufferers are ‘caught in a vicious cycle’ in which over-reliance on pain relievers and, in some cases, inappropriate use of medications can aggravate their condition.
“Doctors and their patients need to be alert for ‘rebound headache’ and limit frequent use of acute analgesic medications, notably opioids such as codeine and morphine derivatives, in the treatment of migraine,” said Prof Stark, a neurologist at The Alfred hospital in Melbourne.
Affecting approximately 200,000 Australians, rebound (or medication overuse) headache occurs when the body becomes acclimatised to a frequently-used pain reliever and then develops a ‘withdrawal’ effect when the medication is ceased.
This often triggers a new headache, prompting the patient to re-introduce the pain reliever and exacerbate a cycle of debilitating symptoms.
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Prof Stark said the diagnosis of rebound headache and withdrawal of the offending medication is extremely important, not only because it can break the migraine cycle, but because patients are less likely to respond to preventative therapy while overusing painkillers.
The MJA study, which involved 191 general practitioners and 649 migraine sufferers, found that therapy that could prevent migraines was significantly under-utilised.
“Our research found that only one in five patients who suffer three or more migraines per month take preventative therapy,” he said.
“These people could benefit enormously from the wide range of preventative medications now available in Australia.
“Migraine prevention should be the primary goal for doctors and their patients. Preventative medication should be considered when headache frequency exceeds two events per month.”
The study also found that 11 per cent of migraine patients were using acute pain relief medication as preventative therapy.
“These patients are at high risk of developing rebound headache,” Prof Stark said.
“Doctors need to ensure patients are not using inappropriate drugs for migraine prevention and that the full range of therapeutic options for migraine prevention is considered.
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Posted by john on July 29th, 2007 — in Fioricet News
The venom of the predatory marine snail Conus Magus is one of the most potent painkillers on the planet. It has a greater potency than morphine, but works in an entirely different way.
The snail’s venom – which it uses to stun and paralyse its prey – targets proteins in cell membranes whose job it is to allow calcium ions to pass in and out.
These so-called “calcium channels” are thought to play an important role in stimulating the nerves that deliver pain signals, as well as in other processes such muscle contraction, heart pace-making and hormone release. The venom targets a particular subgroup known as N-type calcium channels , which play a role in some kinds of pain.
Now, the pharmaceutical company Astrazeneca says it has developed a number of synthetic agents that also act on N-type calcium channels to reduce pain. The company believes they could be used to tackle persistent acute pain where other painkillers have not worked, or cannot be used, in people with cancer or other very severe diseases.
Read the full snail-venom pain relief patent application.
Inhibiting HIV
The human immunodeficiency virus (HIV) has the fiendish ability to rapidly replicate, mutate, and acquire resistance to drugs.
The virus does this by converting viral RNA into viral DNA, then inserting the viral DNA into the genome of a host cell. The RNA to DNA conversion is mediated by HIV enzymes called reverse transcriptase and protease.
Current drug cocktails for HIV treatment inhibit the action of these enzymes, thereby slowing down replication of the virus. However, the rapid emergence of drug resistance limits the ability of these drugs to safely and effectively treat AIDS.
This is why the American pharmaceutical company Pfizer, in New York, US, is looking to inhibit the action of a third enzyme called integrase, which is heavily involved in the process of inserting the viral DNA into the host’s genome.
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Pfizer says it has identified a number of potent and selective HIV-integrase inhibitors which could do the trick. The company suggests that the new compounds, or their salts, inhibit integrase when administered to an infected cell in the correct amount, and can be taken orally as pills or liquids.
Of course, the patent makes no claims about the efficacy of the treatment, but the approach certainly looks interesting.
Read the full inhibiting HIV patent application.
Mimicking pot
Tetrahydrocannabinol, the active ingredient in marijuana, has attracted a lot of attention from drugs companies, and not just because of its psychoactive effects at staff parties.
The compound has a number of potential therapeutic benefits, such as being an appetite stimulator for people with AIDS or cancer patients undergoing chemotherapy.
But fabricating the compound isn’t easy. Tetrahydrocannabinol is destroyed by heat and light, and is easily oxidised in air.
For these reasons, the various ways of making it are either unfeasibly long, or result in a disappointingly low yield. Which is why the Johnson Matthey company (JM) in London, UK, is excited about its latest breakthrough in which it reacts together a diester and olivetol to synthesize tetrahydrocannabinol.
JM says the yield can reach 75%, and the process can easily be scaled up to industrial levels
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Posted by john on July 25th, 2007 — in Fioricet News
Skip the chiropractor’s office and head to a Massage Envy
If you sprain your left knee, you can still get around by shifting your weight to your right knee. If you break your right arm, you can steer a car with your left. And if you cut your thumb, you can still dial your cell phone (however awkwardly) with your index finger. While these situations may be frustrating, none is severe enough to keep you from going about your daily life.
Back pain, however, is another story. You can’t rely on any other body part to “limp” on when your back is throbbing, which is probably why back pain is the second most common reason for missed work behind the common cold. The good news is that back pain can be alleviated, meaning you can go back to using your sick days for what they were intended—playing hooky.
Soothing Relief
While many people today think that back pain relief can only come in the form of painful injections from a physician or awkward manipulation by a chiropractor, that’s simply not the case. In fact, one of the best treatments for easing back pain—massage—has been around for thousands of years.
“Massage is quite effective for treating lower back pain,” says Kristen Sykora, LMT, a spokeswoman for the American Massage Therapy Association. “It’s the MVP in the healthcare arena because it’s more of a hands-on treatment.”
A 2003 study published in the Annals of Internal Medicine found that massage therapy reduced the need for painkillers by 36 percent and was found to be more effective than other therapies, including acupuncture and spinal modification, according to the American Massage Therapy Association. In fact, massage therapy is one of the most commonly used treatments for back pain today.
How Does It Work?
If you’ve ever had a massage, you know it makes you feel good. But how can it relieve back pain and help prevent it from recurring? Its strategy is multifaceted and includes:
+ Muscle relaxation. Massage relaxes the muscle, making it less tense and stiff. It also addresses specific problem areas and works out muscle “knots.”
+ Increased blood flow. Massage promotes blood flow to the area, providing nourishment to the muscles.
+ Endorphin release. Massage calms the nerves that send pain signals to the brain and causes endorphins, the body’s feel good hormone, to be released.
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+ Tension relief. Massage restores flexibility to muscles that are tense due to stress and inactivity.
Working It Out
Massage therapy may make your back quit aching, but don’t expect one session to cure all of your pain. “Your back pain didn’t start overnight,” Sykora says, “so don’t expect it to be cured overnight either.”
How long it takes to achieve long-term relief is dependent upon such factors as the nature of your back pain, your lifestyle, your activity level and your posture. “It’s best for chronic back pain sufferers to be on a maintenance plan for massage—once every three to four weeks,” Sykora says. And do the homework your therapist gives you, she adds. Correct your posture and adjust your work space and work habits. And don’t rule out combining massage with
other therapies, such as exercise.
Physical activity in combination with massage is highly successful. Stronger back muscles will provide more support to the spine. If you’re overweight, losing those extra pounds can ease the load on your back. Yoga, Pilates, tai chi or even simple stretches you do at home will help strengthen your muscles and improve flexibility. Just be sure to talk to your doctor before beginning any new exercise program.
And what would feel better after a moderate workout than to get a massage? More than $25 billion was spent in 2003 by people in search of back pain relief.
Why not spend your money on something that works and is enjoyable? As Sykora says, massage therapy is really important for people to consider because it’s an effective but conservative approach.
(Reprinted with permission from Massage Envy Magazine – Summer 2007)
If you are suffering from back pain or just want to take some time to relax this summer schedule an appointment for a massage at Massage Envy. Your first 1-hour session with us is only $39 and our membership option makes it affordable to take care of yourself year-round.
We have 2 convenient locations in the Kingwood / Atascocita area to serve you.
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Posted by john on July 22nd, 2007 — in Fioricet News
Q: I would like some info about cherries for a friend who suffers from arthritis and gout.
A: A small study in the Journal of Nutrition (June 2003) suggested that sweet cherries could lower uric-acid levels that cause gout. The researchers also observed that “cherries may inhibit inflammatory pathways.”
Readers have been telling us that sour cherries (fresh, dried, frozen, juice or CherryFlex pills) can ease both gout attacks and arthritis pain. Here is one recent account:
“I tried the cherry juice after reading about it in your column. I now get out of bed without back pain (after less than a month). I have sciatica, along with other back issues, and arthritis in both knees. I can do stairs again.”
Q: My husband suffered with jock itch for a long time. He would use medicine to clear it up, but it always returned. Then he tried applying antiperspirant daily to the affected areas, and this solved the problem.
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A: Jock itch is caused by fungus that thrives around moisture. The antiperspirant probably keeps his skin dry and discourages fungal growth.
Q: I read your column about a person concerned about a prescription that was a couple of months past its use-by date. Whenever I receive a prescription from a pharmacy, I ask for the expiration date on the bottle the medication was dispensed from so I can record that date on my prescription bottle and prescription documents. That way, I’m not constrained by the one-year time frame most pharmacists put on the customer’s bottle.
I also save money because I’m not throwing away perfectly good medication and getting new prescriptions filled. I hope others find this helpful.
A: If you make your request at the time you submit your prescription, the pharmacist can allow for the extra time it takes to note the manufacturer’s expiration date. In some states, pharmacists are legally required to display a one-year use-by date, but they are not forbidden to give you the additional information you request.
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Posted by john on July 17th, 2007 — in Fioricet News
There are many reasons as to why a person may find themselves suffering from low back pain. It could be because they have strained some muscles in their back or even some ligaments. It may be caused by them having problems with the disks in their spine. But the most common cause for a person to suffer from low back pain is that their muscles have become weak through inactivity or if a person does something such as lift a heavy box or carrying out some work in the garden.
But there are certain things a person can use or do in order to help with relieving the pain in the lower part of their back. In this article I will take a look at some different kind of low back pain relief you may want to consider using in the future.
One of the first things a person can try is to lay on the floor on their back and get someone to place under their knees. Or they could try instead laying on the floor on their back with their hips and knees bent and then place their feet on a chair in front of them. By doing this a person is actually taking pressure and weight off of their back.
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It is important to note when using this method for helping to relief the back pain, you will need to use this for a couple of days. Plus do not rest for any longer than this or you will find that your muscle become much weaker and so the time it takes to recover will end up taking a lot longer. Therefore although it may hurt in the beginning it is best if you walk around for a few minutes each hour each day as well.
Another way of helping to relieve the pain felt when a person has a problem with their back is to use heating pads. This is ideal for helping to relieve the pain felt when the muscles in the back spasm. This particular kind of low back pain relief treatment should be used for 20 to 30 minutes at a time and work by helping to relieve the tension in the muscles when they go into spasm.
Above we have looked at some of the more natural ways to help with low back pain relief however there are medications that a person can use instead. These can either be purchased over the counter at your local drug store or will need to be prescribed by your doctor.
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Posted by john on July 15th, 2007 — in Fioricet News
The researchers hope that the findings could rapidly advance research into the next generation of painkillers for relief of chronic conditions such as migraine and backache.
The team, from the University of Manchester, examined microscopic amoeboid organisms known as slime moulds in a bid to gain greater insight into P2X pain receptors.
“In humans, P2X receptors look identical to one another and so scientists have had difficulty understanding how they function,” said Dr Chris Thompson, who carried out the research with Professor Alan North and Dr Sam Fountain in the Faculty of Life Sciences.
“By looking at slime mould we were effectively able to turn the evolutionary clock back a billion years to see how a more primitive P2X molecule functions.”
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The team discovered that there was only a 10% similarity between human P2X and the slime mould equivalent. They were therefore able to deduce from evolutionary theory that it was these similar parts of the molecule that probably regulate pain in humans.
“It’s a big step forward in understanding how the molecule works and should make it possible to develop drugs that block the receptors’ actions,” said Dr Thompson.
“Inhibiting P2X as a potential pain-relief therapy would be the Holy Grail of rational drug design and could revolutionise the way we manage chronic pain conditions like back pain and migraine.”
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Posted by john on July 9th, 2007 — in Fioricet News
Choosing an arthritis pain reliever in a pharmacy aisle isn’t as simple as it sounds - there are a dizzying number of choices available. And what about a prescription medicine, rather than an over-the-counter choice?
“Is one safer than another?s questions Dr. Stephen Coyle, chief medical officer at Winnipeg’s Misericordia Health Centre, “We don’t know - many have never been compared before.” Coyle is about to start comparing arthritic drugs in the PRECISION study, hoping to find out which is safest for arthritic patients who are at high risk of cardiovascular disease - such as heart attack or stroke.
The study will compare the effectiveness of Celebrex, Ibuprofen and Naproxen (available by prescription in Canada, but over-the-counter in the United States) in patients with osteoarthritis or rheumatoid arthritis.
All three drugs are pain relievers called nonsteroidal anti-inflammatory drugs, or NSAIDs. Ibuprofen and Naproxen are referred to as traditional NSAIDs, but Celebrex is called a COX-2 inhibitor because it blocks, or inhibits, an enzyme in the body called COX-2 that causes pain and inflammation.
“There have been some questions raised about the safety of both the COX-2 inhibitors and traditional NSAIDs in people who have or are at high risk for heart disease,” explains Coyle. “This study is important because large numbers of people who need long-term treatment for arthritis pain are elderly and more likely to be at risk for cardiovascular disease. We want to make sure they are getting the right kind of therapy.”
Patients in the study will take one of the three medications for six months, with Coyle and research nurse Anne Tesarski monitoring pain levels.
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“We’ll start with the lowest possible dose and increase until people have enough pain relief that they can do their activities of daily living,” says Coyle. Neither the patients nor the researchers will know which medication the patients are taking to rule out any bias. Coyle is quick to point out all patients will be given a protective drug for their stomachs as well.
“All these arthritic drugs produce stomach ulcers,” he explains, “In fact, 30 per cent of all admissions to emergency rooms in North America for adverse drug reactions are for stomach bleeding.”
This is where another “safety” aspect of the study comes into play - patients are educated about the risk of stomach bleeding when they buy these over-the-counter medications for “temporary relief of pain.”
According to Coyle, there are numerous other things people could be doing to reduce their arthritic pain rather than taking medication, such as: weight loss, exercise and strength training, taking food supplements and more.
So why study these three arthritic drugs if people shouldn’t necessarily be taking them anyway?
“People will continue to take them,” says Coyle. “And we need to find out which is safest.”
Coyle has two hypotheses: he predicts one of the medications will be safer than the other two. In other words, people taking that drug will have a lower risk of suffering a heart attack or stroke. He also thinks there will be a decrease in stomach bleeding because people are taking a protective medication.
Misericordia Health Centre is just one centre participating in the PRECISION study - there will be 20,000 patients worldwide.
Misericordia Health Centre provides an array of specialized programs including our Eye Care Centre of Excellence, long-term and interim care, urgent care, ambulatory clinics, diagnostic imaging, laboratory services and pediatric dental surgery. Misericordia also operates the internationally recognized Provincial Health Contact Centre, including Health Links-Info SantЋ.
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